6 Business Insights
Many pharmaceutical materials exhibit polymorphism, which means that, depending upon the given processing conditions, the crystalline form may exist in two or more states. The crystalline states or forms exhibit different levels of thermodynamic stabilities and an unstable form can melt at a temperature significantly less than the melting point of the thermodynamically stable form. Depending upon the conditions used to generate the crystalline form(s), the drug may exhibit one or more unstable, polymorphic crystalline states.
Heat capacity measurement has been performed in order to detect a possible second Tg on nanocomposites of polymethyl methacrylate (PMMA) with silicon oxide nanoparticles of different shape. StepScan? DSC was used for determination of precise heat capacity and HyperDSC? to prevent degradation and identify devitrification of the RAF at elevated temperatures.
Where ?Cp and ?Cp pure are the changes in specific heat at the glass transition temperature, Tg, for the composite, and for the unfilled polymer, respectively. This work suggests an alternative method for determining Cp that takes advantage of fast heating and cooling rates to obtain quantitative Cp in the upper temperature region without having to dwell in that high temperature region to establish an upper isothermal.
This study shows that DSC can be used to study the curing degree of the EVA resin by measuring the residual curing enthalpy. The data show that the residual curing enthalpy can be correlated to the curing time in a linear way. The DSC test is quick and easy.
The concept of High-Throughput Design has gained more and more interest as a way to increase profitability and to decrease research costs. One technique that can increase the ability of a laboratory to evaluate formulations is HyperDSC? or High Ramping Rate DSC. HyperDSC is the ability to quantitatively measure small samples at extreme heating and cooling rates, typically 100-500 °C/min.
In the “Early Drug Discovery Phase” of pharmaceutical development when there is a minimum amount of synthesized drug candidate, quick thermal analysis using a small amount of sample is the norm. The sample amount could be less than 3 mg. Because of the rush to identify possible drug candidates, analytical answers must be given within the day. The STA 6000 with its sensitivity of 0.1 μg allows minimum sample material to obtain reproducible results in half the time.