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PerkinElmer

活体成像试剂

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PerkinElmer公司提供种类丰富的生物发光及荧光活体成像试剂,包括种类丰富的肿瘤发光细胞株、发光细菌、发光底物、慢病毒转染试剂盒、功能性荧光探针、荧光染料、荧光标记试剂盒等,为您在进行疾病相关生物标志物及疾病通路研究中提供广阔的应用选择。

仅供科学研究,非临床诊断用途。

Business Insights (5)
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1-5 的 5 Business Insights

  • 应用文献

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 应用文献

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 应用文献

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 应用文献

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • 海报

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

产品与服务 (112)
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  • In vivo (1)
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  • Targeted (20)
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  • Fluorescence (69)
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1-12 的 112 产品与服务

  • In vivo Fluorescent Agents

    BombesinRSense 680 Fluorescent Imaging Agent

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
  • Bioluminescent Oncology Cell Lines - Bioware

    Bioware? Brite Cell Line HT29 Red-FLuc

    Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
  • XenoLight D-Luciferin K+ Salt

    XenoLight D-Luciferin - K+ Salt Bioluminescent Substrate

    Luciferin is essential in performing your bioluminescent assays, and the quality of your research will depend on the quality of your luciferin. Whether used to perform in vitro assays, or to monitor light production in vivo, PerkinElmer’s high quality luciferin is available at an affordable price.
  • In vivo Fluorescent Agents

    Superhance 680 Fluorescent Imaging Agent

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.?
  • In vivo Fluorescent Agents

    Transferrin-Vivo 750

    Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism. PerkinElmer’s Transferrin-Vivo 750 fluorescent probe is a NIR-labeled in vivo imaging agent that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. Transferrin-Vivo 750 fluorescent agent can also detect normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.
  • Bioluminescent Oncology Cell Lines - Bioware

    Bioware? Brite Cell Line A549 Red-FLuc

    Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
  • Bioware U87 Glioblastoma Bioluminescent Oncology Cell Line

    Bioware? Brite Cell Line U87 MG-Red-FLuc

    Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
  • VivoTag Fluorochrome - 5 mg quantity

    VivoTag 645 – MAL Fluorochrome (5 mg)

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
  • P. aeruginosa bioluminescent bacteria

    Pseudomonas aeruginosa - Xen05

    P. aeruginosa - Xen05 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from a human septicemia isolate (American Type Culture Collection, used under license). P. aeruginosa-Xen05 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • RediFect Lentiviral particles for tranduction of cells

    RediFect Red-FLuc-GFP

    Lentiviral particles for tranduction of mammalian cell lines with a red-shifted luciferase transgene and green fluorescent protein (GFP), for use in in vivo and other applications.
  • Bioluminescent Oncology Cell Lines - Bioware

    Bioware? Brite Cell Line HepG2-Red-FLuc

    Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
  • Bioluminescent Oncology Cell Lines - Bioware

    Bioware? Brite Cell Line PC3 Red-FLuc-GFP

    Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
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