Achieve greater visibility into the mechanisms that cause cardiovascular disease using our phenotypic and target-based solutions. We offer a broad range of products for the cardiovascular researcher.

  • Quickly and simply detect and quantitate the biomarkers of cardiovascular disease with our fast, simple, pre-validated kits and multimode plate readers
  • Effectively conduct targeted binding studies using our radiolabeled ligands and lipids
  • Probe biological processes and study treatment efficacy in animal models from molecular, functional and anatomical perspectives with our in vivo imaging systems
  • Gain deeper insights from phenotypic analysis with our high content screening solutions

Business Insights (8)

1-8 的 8 Business Insights

  • 应用文献

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 应用文献



  • 应用文献

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 应用文献

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 案例?#27835;?/span>

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

产品与服务 (56)

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1-12 的 56 产品与服务

  • 1000x1000_Operetta

    Operetta CLS 高内涵系统

    Operetta CLS? 系统帮助您探索常规实验与复杂创新实验中的生物学信息。通过一系列创?#24405;?#26415;的有机结合,Operetta CLS? 同时满足精细细胞?#38468;?#25104;像对高速、高灵敏?#21462;?#39640;分辨率检测多方面的需求。同时,凭借功能强大的Harmony 4.5版软件,Operetta CLS? 可帮助您发现并定量细微的细胞表型改变。
  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT成像系统

    应用领域涉及骨、肿瘤、心血管?#22836;尾康?#30142;病?#33455;俊uantum GX2 micro CT成像系?#34924;?#24335;灵活,兼容离体样本、小鼠、大鼠及兔子等多?#27835;?#31181;;具备快速、低剂?#24247;?#25195;描模式,适合对活体动物进行长时程?#33455;浚?#20855;备高分辨率成像特点,能够对离体样本进行高分辨扫描。 Quantum GX2 microCT卓越的性能让您不仅得到图像,而是更深入的理解疾病模型。
  • 1000x1000_Opera_Phenix

    Opera Phenix 高内涵系统

    Opera Phenix?高内涵系统是目?#30333;?#21463;期待的高内涵共聚焦技术方案。?#35272;到?#36817;20年的顶尖高内涵产品opera高内涵成像系统积累的丰富成像和应用经验,新一代的opera phenix系统系统专为高内涵表型筛选以?#26696;?#26434;的疾病模型量身打造,例如活细胞、原代细胞,细胞微组织。
  • Receptor-expressing cell lines

    ValiScreen Adrenergic beta 1 (human) cell line

    Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
  • Protein

    Cardiac Troponin T (human), lyophilized (AlphaLISA)

    Human cardiac troponin T standard, for use in running standard curves in AlphaLISA assays.
  • AlphaLISA immunoassay kits

    PAI-1 (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Plasminogen Activator Inhibitor-1 (PAI-1) Detection Kit is designed for detection and quantitation of human PAI-1 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The analyte in this kit consists of the active glycosylated human PAI-1.
  • Diclofenac sodium- Phenylacetic acid C14

    Cholesterol, [4-14C]-, 10μCi (370kBq)

    10 μCi quantities of [4-14C]-Cholesterol are available for your research.
  • CHO HCP LANCE Ultra TR-FRET Detection Kit

    The LANCE??Ultra CHO HCP Detection Kit is designed for detection and quantitation of CHO host cell proteins in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
  • AlphaLISA immunoassay kits

    Cardiac Troponin I (human) AlphaLISA Detection Kit

    The AlphaLISA? Human cardiac Troponin I Detection Kit is designed for detection and quantitation of human cardiac Troponin I in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
  • Membrane Target Systems

    Membrane Target Systems: Angiotensin AT2 (mouse) membrane preparation, in CHO-K1 cells. 400 Units.

    Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
  • Tissue Plasminogen Activator (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Tissue Plasminogen Activator (tPA) Detection Kit is designed for detection and quantitation of human tPA in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both tPA and pro-tPA.
  • Receptor-expressing cell lines

    Angiotensin AT1 AequoScreen cell line

    Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
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