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PerkinElmer

生物治疗

OF

珀金埃尔默提供简单的工作流程解决方案,确保生物治疗研究和患者安全所需的一致、可复验结果。

我们与世界领先的制药、生物技术、合同研究组织合作,协助研发制造新型药物和疫苗。我公司在以下领域具有丰富经验:

  • 抗体表征和测试
  • 靶标确认
  • 免疫原性/安全测试
  • 抗体筛选
  • 污染和质控测试
  • 细胞表征
  • 批次放行验证
  • 功能性测试
  • 疫苗研发
  • PK和功效试验

仅供研究使用。不适用于诊断程序。

Target Identification
Target Identification

靶标确定

在发现新生物治疗药物的早期阶段确定相关疾病标靶。彻底验证每个标靶,避免潜在的下游问题。我公司凭借试管和体内结合的方法,可提供最准确的标靶相关人类疾病的预测。
  • 试管标靶验证细胞成像
  • 标靶发现活体内成像
  • 活体外标靶验证组织成像
Protein Antibody
Protein Antibody

克隆和表达

我们提供一系列微流体、ELISA替代、成像、信息、检测和自动化解决方案,帮助您简化克隆和表达过程中各阶段的工作流程,提高生成的数据的质量:
  • 克隆选择
  • 蛋白质纯化
  • 功能筛选
  • 生物?#27835;?#34920;征
General laboratory
General laboratory

临床前安全

通过高质量、可复验的测试数据,准确定量抗药物抗体(ADA)和药代动力学(PK)/药效学(PD)。无论您的研究涉及单克隆抗体(mAb)、蛋白质或多?#27169;?#25105;公司提供的多种免疫原性、中和抗体(NAb)和PD/PK测试解决方案均可帮助您简化工作流程。
Pipetting
Pipetting

生产和质控

确定过程和产品相关杂质,确保其不会影响生物治疗药物或疫苗研究的质量和安全性。

LabChip?微流体技术可对药用蛋白质进行快速可复验纯?#30830;治觶?#24182;可检测识别浓?#30830;逯档?#33267;5ng/μL的低浓度杂质,从而加速生产和质控过程。

Business Insights (15)
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  • Application Note (11)
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1-12 的 15 Business Insights

  • 应用文献

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 应用文献

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 应用文献

    Preclinical Fluorescence Imaging of Cancer Metastasis to the Lung and Response to Therapy

    Quantitative pre-clinical fluorescence imaging transcends the boundaries of traditional optical imaging of biological structures and physiology by providing information at the molecular level about disease states and therapeutic response. Fluorescent Pre-clinical Imaging Agents and FMT? (Fluorescence Molecular Tomography) Quantitative Pre-clinical Imaging Systems represent powerful tools for research and drug development in the imaging of biological processes and pharmaceutical activity in living animals.

  • 应用文献

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 应用文献

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 应用文献

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 应用文献

    用高内涵筛选系统进行FRET测定

    在这个实验中,我们建立了一种快速稳定的基于FRET的高内涵检测...

  • 应用文献

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 应用文献

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 应用文献

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 应用文献

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • 海报

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

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1-12 的 186 产品与服务

  • EnSight Multimode Plate Reader

    EnSight 多模式读板仪

    EnSight? 多模式读板仪是一台整合了多标记、无标记和显微成像技术的桌面式一体化检测平台。其整孔成像&在线数据?#27835;?#36895;?#30830;?#24120;快,可以在五分钟内完成384?#35013;?#25972;板的图像获取及?#27835;觥?#35813;仪器采用预置模块化设计,结合基于Kaleido软件的数据采集和?#27835;?#27969;程,是一台真正的全能且高产的多模式读板仪。
  • JANUS G3 Btx Pro-Plus

    JANUS G3 BioTx Pro Plus工作站

    JANUS? G3 Bio Tx Pro Plus为高通量工艺开发提供完全的“无人值守的”自动化,实现从珍贵的起始材料及有限?#35797;?#20013;获取更多数据。
  • EnVision 2105 multimode plate reader

    EnVision 多模式读板仪

    EnVision 多模式读板仪在所有检测模式下都能提供最快的检测速?#21462;?#36229;高通量及最高的灵敏度,为您的高通?#21487;?#36873;提供可靠的仪器及结果,以满足您日益加速的新实验需求。
  • LabChip GXII Touch System

    LabChip GXII Touch Protein Characterization System

    LabChip GXII Touch系统是是准确、可重复的蛋白样本?#27835;?#23436;整解决方案。LabChip GXII Touch HT利用微流体技术减少了处理耗时的SDS聚丙烯酰胺凝胶电泳的需求,并且以更少的时间和金钱来提供卓越的结果。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT 小动物活体成像系统

    IVIS? Lumina LT是PerkinElmer最新推出的第三代高灵敏度小动物活体光学二维成像平台。
  • G8 PET/CT benchtop scanner for preclinical imaging research

    G8 PET/CT 成像系统集

    PerkinElmer 公司最新研发的 G8 PET/CT 二合一成像系统集?#38378;烁?#28789;敏度 PET 成像及快速、低剂量 microCT 成像,使研究者在进行功能或代谢研究的同?#20445;?#33719;取结构性图像数据。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III 小动物活体成像系统

    IVIS? Lumina III是PerkinElmer最新推出的第三代高灵敏度多光谱小动物活体光学二维成像平台。
  • 1000x1000_Operetta

    Operetta CLS 高内涵系统

    Operetta CLS? 系统帮助您探索常规实验与复杂创新实验中的生物学信息。通过一系列创新技术的有机结合,Operetta CLS? 同时满足精细细胞细节成像对高速、高灵敏?#21462;?#39640;分辨率检测多方面的需求。同?#20445;?#20973;借功能强大的Harmony 4.5版软件,Operetta CLS? 可帮助您发现并定量细微的细胞表型改变。
  • JANUS G3 BioTx Pro Workstation

    JANUS G3 BioTX Pro Workstation

    性价比高的紧凑型JANUS? G3 BioTx Pro自动化工作平台可实现可重复性、节省时间的小规模蛋白提纯及样本制备, 适用于?#27835;?#34507;白质表征,通过上游和下游工艺中的设计实验来支持质量。

    适用于以下应用的理想工作站:

    • 表达优化
    • 细胞株选择
    • 提纯工艺开发
    • 生物?#27835;?#26679;本制备
  • FMT In Vivo Imaging Instrument

    FMT 4000 In Vivo Imaging System

    The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. It comes with four excitation laser channels (635, 680, 750, & 790 nm).
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum 小动物活体成像系统

    IVIS? Spectrum 小动物活体光学成像系统是全球首台同时具备生物发光、荧光、化学发光及?#26032;卓品?#20108;维/三维成像功能的系统,代表了目前活体光学成像技术的最高水?#20581;?
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT? 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
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